Tryptophan Drug Interactions

Antidepressants, benzodiazepines, and MAOIs are among the medications that can interact negatively with tryptophan. Drug interactions with tryptophan may increase the risk of a dangerous group of symptoms called serotonin syndrome. Other interactions may cause sexual side effects, uncontrollable muscle movements, and even life-threatening side effects. To avoid these problems, make sure your healthcare provider is aware of other medications you are taking before using tryptophan.

 

An Introduction to Tryptophan Drug Interactions

Even though tryptophan (also known as L-tryptophan) is a natural product, it can potentially interact with some medicines. Some of these medicines that may lead to tryptophan interactions include:
 

 

 

  • Meperidine (Demerol®)
     
  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Phenothiazine medications, including:

 

 

 

 

(Tryptophan Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;