Antidepressants, benzodiazepines, and MAOIs are among the medications that can interact negatively with tryptophan. Drug interactions with tryptophan may increase the risk of a dangerous group of symptoms called serotonin syndrome. Other interactions may cause sexual side effects, uncontrollable muscle movements, and even life-threatening side effects. To avoid these problems, make sure your healthcare provider is aware of other medications you are taking before using tryptophan.
Even though tryptophan (also known as L-tryptophan) is a natural product, it can potentially interact with some medicines. Some of these medicines that may lead to tryptophan interactions include: