Sonata Drug Interactions

When certain drugs (such as protease inhibitors or certain antibiotics) are taken at the same time as Sonata, drug interactions may develop. Since these interactions can significantly increase the level of Sonata in your blood and lead to side effects, your healthcare provider may need to monitor you more closely or adjust your medication dosage as needed.

Sonata Drug Interactions: An Overview

Sonata® (zaleplon) can potentially interact with many drugs. Some of the drugs that may lead to Sonata drug interactions include:
 
  • Alcohol
     
  • Certain antibiotics or antifungals, including:
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain anticonvulsants, including:
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®)
     
  • Thioridazine (Mellaril®).
     

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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