Sonata Drug Interactions

Imipramine (Tofranil)
Taking Sonata with imipramine can increase your risks of developing side effects (especially drowsiness). Your healthcare provider may need to adjust your dose of these medications.
 
Nefazodone (Serzone)
Taking Sonata with nefazodone can increase the level of Sonata in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Nevirapine (Viramune)
Taking Sonata with nevirapine can decrease the level of Sonata in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medicaions.
 
Nicardipine (Cardene)
Taking Sonata with nicardipine can increase the level of Sonata in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these two medications together.
 
Promethazine (Phenergan, Promethagan)
Taking Sonata with promethazine can increase the level of Sonata in your blood, increasing your chance of developing side effects. Your healthcare provider may need to adjust your dose of these medications.
 
Protease Inhibitors
Taking Sonata with protease inhibitors can increase the level of Sonata in the blood, increasing your chance of developing side effects. Talk to your healthcare provider before taking these medications together.
 
Rifamycin Antibiotics
Taking Sonata with rifamycin antibiotics can decrease the level of Sonata in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Thioridazine (Mellaril)
Taking Sonata with thioridazine can increase your risk of side effects (especially drowsiness). Talk to your healthcare provider before taking these two medications together.
 
(Sonata Drug Interactions Continued: Page 4)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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