Silenor Drug Interactions

Silenor Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Silenor is combined with any of the drugs listed above.
Do not drink alcohol while taking Silenor. Alcohol will increase the effects of Silenor on the brain, further impairing your ability to drive or operate heavy machinery (and potentially even increasing the risk of dangerous problems, such as a coma or decreased breathing). Additionally, alcohol seems to increase the risk of "sleep driving" or other complex tasks performed during sleep that sometimes occur in people taking sleep medications.
Arrhythmia Medications
Taking doxepin (the active ingredient in Silenor) with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. However, it is thought that this is probably not a significant problem with the low dosage of doxepin in Silenor. Also, certain arrhythmia medications can increase the level of Silenor in your blood, increasing your risk of side effects. Talk to your healthcare provider before taking these medications together.
Cimetidine (Tagamet)
Taking Silenor with cimetidine can increase the level of Silenor in your blood, increasing your chance of side effects. Your healthcare provider may need to adjust your dose of Silenor (see Silenor Dosage) or may suggest an alternative to cimetidine.
Medications That Cause Drowsiness
Silenor is a central nervous system (CNS) depressant, meaning it slows down the activity of the brain, leading to drowsiness and (at high doses) more serious problems, such as decreased breathing. Combining Silenor with other CNS depressants (medications that are usually easily identified by their ability to cause drowsiness) may increase the risk of serious problems. Check with your healthcare provider before taking Silenor with another CNS depressant.

Silenor Medication Information

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