Melatonin

Melatonin is a naturally occurring hormone that is commonly used as a supplement to help treat sleeping disorders. It can also be used to treat cancer (when combined with standard cancer treatment), prevent or treat Alzheimer's disease, and prevent cluster or migraine headaches. Most melatonin supplements on the market today are synthetic versions of the hormone. Side effects may include dizziness, nausea, and depression.

What Is Melatonin?

Melatonin is a hormone produced by the pineal gland (a small gland in the brain) that is available as a supplement. As a supplement, it is not regulated as tightly as prescription or non-prescription medications. Most of the supplements on the market today are synthetic versions of this naturally occurring hormone. Melatonin is often claimed to be helpful for the following uses:
 
(Click Benefits of Melatonin for more information, including additional uses.)
 

How Does Melatonin Work?

Melatonin is a naturally occurring hormone. It seems to play an important role in the circadian rhythm (the daily internal rhythm that regulates sleeping, waking, and other functions). Normally, levels of this hormone increase at night and decrease during the day. Sometimes, people have low melatonin levels or levels that are a bit mixed up, with high levels during the day and low levels at night. It is thought that such problems can lead to sleep disorders. Taking it at night helps to replicate the natural rhythm, which can help people reestablish normal sleeping patterns.
 
Melatonin is a powerful antioxidant, which is why it may have some usefulness for preventing cancer or other conditions of aging (such as Alzheimer's disease). It is not known how it might work for preventing headaches. For cancer treatment, it seems to work in numerous ways. It may directly inhibit tumor growth, affect hormones that stimulate cancers, and also help prevent or lessen some of the side effects of chemotherapy.
 

Is It Effective?

Melatonin appears to be effective for many uses, but further research is needed to establish how to safely and effectively use the product.
 
(Click Does Melatonin Work? for more information.)
 

Dosing Information

Melatonin is available in a large range of doses. For many uses, the safe and effective dose has not yet been established. However, general dosing information is available based on clinical studies and years of experience with such products.
 
(Click Melatonin Dosage for more information.)
 

Side Effects of Melatonin

Many people believe that "natural" products, such as melatonin, have no side effects. However, some natural products cause side effects, some of which can be quite serious. This supplement can cause side effects such as:
 
(Click Melatonin Side Effects to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
 

Drug Interactions

Melatonin may interact with several other medications or supplements (see Melatonin Drug Interactions).
 

Is It Safe?

Some people may be more likely to experience problems due to melatonin. Therefore, you should talk with your healthcare provider before taking it if you have:
 
Also, let your healthcare provider know if you are:
 
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
(Click Melatonin Safety for more information, including any available warnings and precautions.)
 

What If I Take an Overdose?

It is not known exactly what to expect from a melatonin overdose, although there have been reports of the following problems occurring:
 
  • Confusion
  • Liver problems
  • Eye problems
  • Seizures
  • Headaches
  • Psychotic behavior or thinking.
     
If you think you may have taken too much, seek immediate medical attention.
 
(Click Melatonin Overdose for more information.)
 

How Should Melatonin Be Stored?

Refer to the label of your individual melatonin product for information on how to best store it. Keep melatonin and all other medications or supplements out of the reach of children.
 
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