Melatonin Side Effects

Daytime drowsiness, dizziness, and abdominal cramps are some of the side effects that may occur with melatonin. Side effects can usually be lessened by making adjustments in the dosage or by switching from a daytime to nighttime dosage. There are also a number of potentially serious side effects of melatonin that may require immediate medical attention, such as anxiety, low blood pressure, or seizures.

 

Does Melatonin Cause Side Effects?

As with any medication or supplement, side effects are possible with melatonin. Interestingly, melatonin is more likely to have bothersome side effects if you take it at the wrong time of the day (usually, it should be taken at night).
 

Possible Melatonin Side Effects

Possible bothersome (although not usually serious) melatonin side effects may include:
 
  • Daytime drowsiness
  • Dizziness
  • Headaches
  • Abdominal cramps (stomach cramps)
  • Irritability
  • Nausea and vomiting
  • Shakiness (tremor).
     
Often, these side effects can be lessened by simple adjustments in the melatonin dosage or in the timing of the dosage. For instance, taking melatonin in the morning is likely to interfere with the normal sleep-wake cycle, possibly leading to daytime drowsiness or perhaps even insomnia at night. Switching to an evening dose may reduce such side effects. Also, lowering the dose may help with many side effects.
 

Melatonin Side Effects to Report

Some side effects with melatonin, while occurring infrequently, are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
 
  • Low blood pressure (known medically as hypertension)
  • Depression (or a worsening of depression symptoms)
  • Anxiety
  • Confusion
  • Seizures
  • Signs of an allergic reaction, such as a rash, hives, itching, swelling of the mouth or throat, wheezing, or difficulty breathing.
     
(Melatonin Side Effects Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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