Insomnia Channel
Topics & Medications
Quicklinks
Related Channels
Melatonin Drug Interactions
A number of medications may interact negatively with melatonin. Drug interactions may occur if melatonin is taken with antidepressants, narcotics and opiates, calcium channel blockers, or hormonal contraceptives. Drug interactions with melatonin such as these could lead to an increased risk for developing side effects, such as drowsiness, confusion, memory loss, and difficulty breathing.
Interested in a Discount on Melatonin?
Enter your email address to see if eMedTV's free DiscountRx service has a program that could help you save on your prescription(s).
Thank you!
Thank you for your interest in DiscountRx from eMedTV. An email has been sent to the address you provided. Please follow the link within that email to see what offers may be available.
Melatonin can potentially interact with several other medicines. Some of the medicines that may lead to melatonin drug interactions include:
- Alcohol
- Antidepressants
- Antipsychotic medications, such as:
- Aripiprazole (Abilify®)
- Asenapine (Saphris®)
- Chlorpromazine (Thorazine®)
- Clozapine (Clozaril®, FazaClo®)
- Fluphenazine (Prolixin®)
- Haloperidol (Haldol®)
- Iloperidone (Fanapt®)
- Loxapine (Adasuve™, Loxitane®)
- Lurasidone (Latuda®)
- Molindone (Moban®)
- Olanzapine (Zyprexa®, Symbyax®)
- Paliperidone (Invega®)
- Perphenazine (Trilafon®)
- Pimozide (Orap®)
- Prochlorperazine (Compazine®, Compro®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Thioridazine (Mellaril®)
- Thiothixene (Navane®)
- Trifluoperazine (Stelazine®)
- Ziprasidone (Geodon®)
- Barbiturates, including (but not limited to):
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Benzodiazepines, such as:
- Calcium channel blockers, such as:
- Amlodipine (Norvasc®)
- Diltiazem (Cardizem®, Cardizem CD®, Cardizem LA®, Cartia XT®, Dilacor XR®, Dilt-CD®, Diltia XT®, Dilt-XR®, Taztia XT®, Tiazac®)
- Felodipine (Plendil®)
- Isradipine (Dynacirc®, Dynacirc CR®)
- Nisoldipine (Sular®)
- Nicardipine (Cardene®, Cardene SR®)
- Nifedipine (Adalat CC®, Afeditab CR®, Nifediac CC®, Nifedical XL®, Procardia®, Procardia XL®)
- Nimodipine (Nimotop®)
- Verapamil (Calan®, Calan SR®, Covera-HS®, Isoptin SR®, Verelan®, Verelan PM®)
- Diabetes medications (both oral and injectable)
- Hormonal contraceptives (such as birth control pills, patches, or rings)
- Narcotics or opiates, such as morphine (MSIR®), oxycodone (OxyContin®), or hydrocodone (Lortab®, Vicodin®)
- Other sleep medications
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD