Melatonin Drug Interactions

Melatonin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when melatonin is combined with any of the drugs listed above.
 
Alcohol
Combining alcohol with melatonin can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. It is best to avoid alcohol while taking melatonin.
 
Antidepressant Medications
Combining an antidepressant with melatonin can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. In addition, some antidepressants can increase the level of melatonin in your blood, which increases the risk of side effects even more. Also, melatonin may worsen depression symptoms in some people. Make sure to talk to your healthcare provider before taking melatonin with an antidepressant, as you may need to be monitored more closely.
 
Antipsychotic Medications
Combining an antipsychotic medication with melatonin can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking melatonin with an antipsychotic medication. If you are taking an antipsychotic medication, do not treat yourself for insomnia or any other sleep disorder without checking with your healthcare provider first.
 
Barbiturates
Combining a barbiturate with melatonin can increase your risk of side effects, such as drowsiness, confusion, memory loss, or difficulty breathing. Serious side effects may also occur. Make sure to talk to your healthcare provider before taking melatonin with a barbiturate.
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