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Although most people tolerate Lunesta well, it is still possible to develop certain side effects while taking Lunesta. Side effects that are most commonly reported include drowsiness, headache, and infections. Rare but possible side effects (occurring in less than 1 percent of patients) may include high blood pressure, sensitivity to the sun, and hiccups. When Lunesta side effects occur, they are typically minor, but be sure to seek medical attention immediately if you develop serious problems such as suicidal thoughts, anxiety, or hallucinations.

Lunesta Side Effects: An Introduction

As with any medicine, there are possible side effects with Lunesta® (eszopiclone). However, not everyone who takes the medicine will experience side effects. In fact, most people tolerate Lunesta well. When Lunesta side effects do occur, they are generally minor and either require no treatment or can easily be treated by you or your healthcare provider.
(The Lunesta side effects discussed below are not a complete list of side effects reported with this drug. Your healthcare provider can discuss a more complete list of possible side effects with you.)

Common Side Effects of Lunesta

Lunesta has been studied extensively in clinical trials, with many people having been evaluated. In these studies, side effects occurring in the group of people taking the drug are always documented and compared to the side effects that occur in a similar group of people not taking the medicine. As a result, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
Based on these studies, the most common side effects of Lunesta include:
  • Unpleasant taste -- in up to 34 percent of people 
  • Headache -- up to 21 percent
  • Drowsiness -- up to 10 percent
  • Infections, such as a urinary tract infection (UTI) -- up to 10 percent
  • Dry mouth -- up to 7 percent
  • Dizziness -- up to 7 percent
  • Heartburn or upset stomach -- up to 6 percent
  • Pain -- up to 5 percent.
Other Lunesta side effects (occurring in more than 1 percent of people) include:
  • Nausea or vomiting
  • Accidental injury
  • Diarrhea
  • Decreased libido, also known as sex drive (see Lunesta Sexual Side Effects)
  • Breast enlargement in men
  • Painful periods (including menstrual cramps).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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