Insomnia Home > Drug Interactions With Estazolam

If estazolam is combined with other medications, negative interactions could occur. These drug interactions with estazolam can increase your risk of side effects, such as confusion, memory loss, and difficulty breathing. Medications that can interact with estazolam include antidepressants, seizure medications, and antipsychotic medicines. Prior to starting treatment, talk to your healthcare provider about any drug interactions with estazolam that may apply to you.

Drug Interactions With Estazolam: An Overview

Estazolam (ProSom®) can potentially interact with a number of other medications, especially other medications that affect the brain. Some of the medicines that may lead to estazolam drug interactions include:



  • Barbiturates, including:


    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)




  • Other sleep medications
  • Seizure medications.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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