Lunesta Drug Interactions

There are many drugs that can lead to negative interactions when taken together with Lunesta. Drug interactions may significantly increase the level of Lunesta in your blood, which increases your risk of developing side effects. Lunesta drug interactions may occur if the sleeping medicine is taken with alcohol, certain anticonvulsants, protease inhibitors, or rifamycin antibiotics, among other drugs.

 

Lunesta Drug Interactions: An Overview

Lunesta® (eszopiclone) can potentially interact with many drugs. Some of the drugs that may lead to Lunesta interactions include:
 
  • Alcohol
     
  • Certain antibiotics or antifungals, including:
o Clarithromycin (Biaxin®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®)
  • Certain anticonvulsants, including:
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Rifamycin antibiotics, including rifabutin (Mycobutin®), rifampin (Rifadin®), and rifapentine (Priftin®).
     
(Lunesta Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;