L-glutamine supplementation by IV may be useful for preventing problems in people who are critically ill (such as after severe physical trauma) and may aid in recovery after certain types of surgery. Oral L-glutamine supplementation may be useful for helping people with HIV or AIDS gain weight and may decrease the risk of mouth sores in people undergoing chemotherapy. It is not known if it is effective for most other uses.
(Click Does Glutamine Work? for more information.)
There are no clear guidelines for a safe and effective dose for most uses. Because L-glutamine is a non-essential amino acid, there is no Recommended Dietary Allowance (RDA). Be sure to follow the specific instructions on your particular product.
(Click L-Glutamine Dosage for more information.)
Most people generally tolerate L-glutamine well, but many people find the grittiness of L-glutamine powder to be rather unpleasant. Although there are several theoretical side effects that are possible with this supplement, most studies have indicated that it is unlikely to cause significant side effects.
(Click Side Effects of L-Glutamine to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
L-glutamine can interact with a few medications (see Drug Interactions With L-Glutamine).